Unit · year 2
BU-202 · Cell Signalling & Membranes
Threads regulation · information24 lectures7 concepts
How cells transport materials and communicate.
Lectures
| L01 | Membrane Structure Revisited — |
| L02 | Simple and Facilitated Diffusion |
| L03 | Channel and Carrier Proteins |
| L04 | Primary Active Transport and the Sodium–Potassium Pump |
| L05 | Secondary Active Transport and Cotransport |
| L06 | Bulk Transport: Endocytosis and Exocytosis |
| L07 | Ion Gradients Across Membranes |
| L08 | The Nernst Equation in Biology |
| L09 | The Resting Membrane Potential |
| L10 | The Goldman Equation and Multiple Ions |
| L11 | Cell Communication: An Overview |
| L12 | Autocrine, Paracrine, and Endocrine Signalling |
| L13 | Receptor–Ligand Binding |
| L14 | Affinity, Specificity, and Saturation |
| L15 | Dissociation Constants and Binding Curves |
| L16 | Signal Transduction: The Three Stages |
| L17 | G-Protein-Coupled Receptors |
| L18 | Receptor Tyrosine Kinases |
| L19 | Second Messengers: cAMP |
| L20 | Calcium as a Second Messenger |
| L21 | The Phosphoinositide Pathway |
| L22 | Signal Amplification and Cascades |
| L23 | Signal Termination and Desensitisation |
| L24 | Synthesis: Membranes as Interfaces of Control |
Concepts in this unit
T-036
Membrane transport
Passive, facilitated and active movement across membranes.
T-037
Signal transduction
Converting an external signal into a cellular response.
T-038
Receptor-ligand binding
Specificity and affinity in molecular recognition.
T-039
Second messengers
Amplifying and relaying signals inside the cell.
T-040
The resting membrane potential
The Nernst equation applied to ion gradients.
T-182
The oxygen-haemoglobin dissociation curve
Four cooperating sites make oxygen binding sigmoid: saturation is the log-derivative of the Adair binding polynomial, and the Hill coefficient is its variance.
T-183
Renal clearance and glomerular filtration rate
Urine concentration times urine flow over plasma concentration gives the plasma volume cleared per minute; for a marker the tubule ignores, that is the GFR.